Effect of glucomannan and the dosage form on ethinylestradiol oral absorption in rabbits

Repositorio Dspace/Manakin

Effect of glucomannan and the dosage form on ethinylestradiol oral absorption in rabbits

Mostrar el registro completo del ítem

Título: Effect of glucomannan and the dosage form on ethinylestradiol oral absorption in rabbits
Autor: González, Aranzazu;Fernández, Nélida;Sahagún, Ana M.;García, Juan J.;Diez, M. José;Castro, Luis J.;Sierra, Matilde
Facultad/Centro: Facultad de Veterinaria
Area de conocimiento: Farmacologia
Resumen: To the beneficial properties of dietary fiber in human health, several disadvantages can be added as the possible modification of the bioavailability of other drugs when administered by the oral route. In this study, the influence of glucomannan in the oral bioavailability of ethinyl estradiol (EE), when administered to female rabbits in two different dosage forms (enteric capsules and dispersed in water), was established. To carry out the study, three groups of six animals each were used. All animals received 1 mg kg 1 oral EE, and rabbits in groups 2 and 3 received 1.5 g glucomannan dispersed in water or in enteric capsules, respectively, immediately before EE. When comparing the results obtained after the administration of EE/glucomannan dispersed in water with those obtained after the administration of this estrogen without fiber, we can see that Cmax is 1.4 times lower, AUC 1.9 times lower and that tmax is identical (10 min). However, after the administration of fiber in enteric capsules, AUC and Cmax are higher (4.1 and 7.8 times, respectively) than when the estrogen was administered alone, and also, there is a delay in tmax (20 min). After the administration of glucomannan in the enteric capsule, the fiber forms, as in the stomach, a highly viscous solution in the gut that would limit EE access to the mucosal surface delaying its absorption. However, this effect could be compensated by a reduction of EE metabolism in the intestinal wall, leading to a higher absorption of the estrogen.
Descripción física: P. 423-427
Revisión por pares: SI
Editor: ARHP
Datos: Contraception, 2004, n. 70
URI: http://hdl.handle.net/10612/4476
Fecha: 2004-07-10
Tipo: info:eu-repo/semantics/article
Materia: Ecología. Medio ambiente
Farmacología
Zoología
Palabras clave: Ethinyl estradiol
Glucomannan
Rabbits
Fiber
Pharmacokinetics
Oral absorption
Ratones
Derechos de acceso: info:eu-repo/semantics/openAccess
Exportar referencia a Refworks:


Ficheros en el ítem

Ficheros Tamaño Formato Ver
2004Contraception70 423-7.pdf 136.8Kb PDF Ver/Abrir

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro completo del ítem

Buscar en BULERIA


Búsqueda avanzada

Listar

Mi cuenta

Estadísticas