Bioavailability of levamisole administered by subcutaneous and oral routes in rabbits

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Bioavailability of levamisole administered by subcutaneous and oral routes in rabbits

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Title: Bioavailability of levamisole administered by subcutaneous and oral routes in rabbits
Author: García, Juan J.;Diez, M. José;Sierra, Matilde;Terán, M. Teresa
xmlui.dri2xhtml.METS-1.0.item-contributor: Facultad de Veterinaria
xmlui.dri2xhtml.METS-1.0.item-area: Farmacologia
Abstract: The bioavailability of levamisole in rabbits was determined after subcutaneous and oral administration at three dose levels of 12.5, 16.0 and 20.0 mg/kg. After non-compartmental analysis the mean values obtained were: Cmax = 3.54, 4.51 and 5.39 µg/ml; tmax = 12.0, 22.0 and 20.0 min; F = 134.8, 105.4 and 124.1% after subcutaneous administration for each dose, respectively, and Cmax = 0.71, 1.32 and 1.77 µg/ml; tmax = 46.0, 96.0 and 84.0 min; F = 53.0, 62.0 and 80.7% after oral administration. The extent and rate of absorption from the two routes differed sign.ificantly, except for tmax at the 12.5 mg/kg dose. After compartmental analysis the pharmacokinetics of levamisole was characteristic of a two-compartment open model in 13 rabbits and of a one-compartment open model in two rabbits after subcutaneous administration, while it was two compartmental in nine and one compartmental in six rabbits after oral admini­ stration. The kª values were 0.321, 0.145 and 0.145 min-1 after subcutaneous adininistration and 0.054, 0.023 and 0.027 min- 1 after oral administration. There were no significant differences between the values of Cmax• tmax and AUC calculated by compartmental and non-compartmental analysis.
xmlui.dri2xhtml.METS-1.0.item-desfisica: P. 135-140
xmlui.dri2xhtml.METS-1.0.item-peerreviewed: SI
Publisher: Blackwell Scientific Publications
xmlui.dri2xhtml.METS-1.0.item-citation: Journal of Veterinary Pharmacology and Therapeutics, 1994, n. 17
URI: http://hdl.handle.net/10612/4530
Date: 1994-02-09
xmlui.dri2xhtml.METS-1.0.item-tipo: info:eu-repo/semantics/article
Subject: Ecología. Medio ambiente
Farmacología
Zoología
xmlui.dri2xhtml.METS-1.0.item-palclave: Bioavailability
Levamisole
Oral routes
Subcutaneous
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