Effects of dietary factors on levodopa pharmacokinetics

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Effects of dietary factors on levodopa pharmacokinetics

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dc.contributor Facultad de Veterinaria es_ES
dc.contributor.author Fernández, Nélida
dc.contributor.author García, Juan J.
dc.contributor.author Diez, M. José
dc.contributor.author Sahagún, Ana M.
dc.contributor.author Diez, Raquel
dc.contributor.author Sierra, Matilde
dc.contributor.other Farmacologia es_ES
dc.date 2010-07-15
dc.date.accessioned 2015-09-03T13:34:10Z
dc.date.available 2015-09-03T13:34:10Z
dc.date.issued 2015-09-03
dc.identifier.citation Expert opinion on drug metabolism and toxicology, 2010, n. 6 es_ES
dc.identifier.uri http://hdl.handle.net/10612/4552
dc.description P. 633-642 es_ES
dc.description.abstract lmportance of the fíeld: Levodopa is the most effective treatment for Parkinson's disease, so it is important to understand the pharmacokinetic an d pharmacodynamic features of this drug. Considering the pharmaco­ kinetics of levodopa and the factors that can modify it are essential for the clinician when prescribing levodopa products in order to maximize their therapeutic effects. · Areas covered in thís review: This pa per reviews the studies carried out eva luating the interaction between levodopa and dietary factors. What the reader will gain: The reader will gain a greater understanding of the different dietary factors that can affect levodopa pharmacokinetics and, thus, the therapeutic response that is obtained with this drug in several situations. Take home message: An understanding of the pharmacokinetics of any drug is crucial for the establishment of its optima! therapeutic regimen, but this assumes a special importance with levodopa, due to its extensive presystemic rnetabolism, rapid absorption in the proximal small intestine and short plasma ha lf-life. Major problems with levodopa treatment are the fluctuations in clin­ ical response experienced in patients with advanced Parkinson's disease that sometimes are related to the peripheral pharmacokinetics of levodopa. Stu­ dies of levodopa interactions are very important to improve patient response to this drug. es_ES
dc.language eng es_ES
dc.publisher Ashley Publications es_ES
dc.subject Farmacología es_ES
dc.subject Medicina. Salud es_ES
dc.subject.other Dietary factors es_ES
dc.subject.other Interaction es_ES
dc.subject.other Levodopa es_ES
dc.subject.other Pharmacokinetics es_ES
dc.title Effects of dietary factors on levodopa pharmacokinetics es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.description.peerreviewed SI es_ES

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