c-Jun N-Terminal Kinase 1 Is Required for Toll-Like Receptor 1 Gene Expression in Macrophages

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c-Jun N-Terminal Kinase 1 Is Required for Toll-Like Receptor 1 Gene Expression in Macrophages

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dc.contributor Facultad de Ciencias Biologicas y Ambientales es_ES
dc.contributor.author Izadi, Hooman
dc.contributor.author Motameni, Amirreza T.
dc.contributor.author Bates, Tonya C.
dc.contributor.author Olivera, Elias R.
dc.contributor.author Villar-Suárez, V.
dc.contributor.author Joshi, Ila
dc.contributor.author Garg, Renu
dc.contributor.author Osborne, Barbara A.
dc.contributor.author Davis, Roger J.
dc.contributor.author Rincón, Mercedes
dc.contributor.author Anguita, Juan
dc.contributor.other Bioquimica y Biologia Molecular es_ES
dc.date 2007-04-23
dc.date.accessioned 2017-07-19T12:48:09Z
dc.date.available 2017-07-19T12:48:09Z
dc.date.issued 2017-07-19
dc.identifier.citation Infection and Immunity, 2007 (octubre) es_ES
dc.identifier.uri http://hdl.handle.net/10612/6448
dc.description P. 5027-5034 es_ES
dc.description.abstract The regulation of innate immune responses to pathogens occurs through the interaction of Toll-like receptors (TLRs) with pathogen-associated molecular patterns and the activation of several signaling pathways whose contribution to the overall innate immune response to pathogens is poorly understood. We demonstrate a mechanism of control of murine macrophage responses mediated by TLR1/2 heterodimers through c-Jun N-terminal kinase 1 (JNK1) activity. JNK controls tumor necrosis factor alpha production and TLR-mediated macrophage responses to Borrelia burgdorferi, the causative agent of Lyme disease, and the TLR1/TLR2-specific agonist PAM3CSK4. JNK1, but not JNK2, activity regulates the expression of the tlr1 gene in the macrophage cell line RAW264.7, as well as in primary CD11b cells. We also show that the proximal promoter region of the human tlr1 gene contains an AP-1 binding site that is subjected to regulation by the kinase and binds two complexes that involve the JNK substrates c-Jun, JunD, and ATF-2. These results demonstrate that JNK1 regulates the response to TLR1/2 ligands and suggest a positive feedback loop that may serve to increase the innate immune response to the spirochete es_ES
dc.language spa es_ES
dc.publisher American Society for Microbiology es_ES
dc.subject Bioquímica es_ES
dc.subject.other Microbiología es_ES
dc.subject.other Inmunología es_ES
dc.subject.other Toll-like receptors (TLRs) es_ES
dc.subject.other Macrophages es_ES
dc.subject.other N-terminal kinase 1 (JNK1) es_ES
dc.title c-Jun N-Terminal Kinase 1 Is Required for Toll-Like Receptor 1 Gene Expression in Macrophages es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.description.peerreviewed SI es_ES

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