Acute phase protein concentrations in colostrum-deprived pigs immunized with subunit and commercial vaccines against Glässer’s disease

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Acute phase protein concentrations in colostrum-deprived pigs immunized with subunit and commercial vaccines against Glässer’s disease

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dc.contributor Facultad de Veterinaria es_ES
dc.contributor.author Martínez Martínez, Sonia
dc.contributor.author Frandoloso, Rafael
dc.contributor.author Gutiérrez Martín, César Bernardo
dc.contributor.author Lampreave, Fermín
dc.contributor.author García-Iglesias, María-José
dc.contributor.author Pérez-Martínez, Claudia
dc.contributor.author Rodríguez Ferri, Elías Fernando
dc.contributor.other Sanidad Animal es_ES
dc.date 2011-11-23
dc.date.accessioned 2017-08-01T22:39:10Z
dc.date.available 2017-08-01T22:39:10Z
dc.date.issued 2017-08-02
dc.identifier.citation Veterinary Immunology and Immunopathology, 2011 es_ES
dc.identifier.uri http://hdl.handle.net/10612/6471
dc.description 8 p. es_ES
dc.description.abstract Haemophilus parasuis is the etiological agent of Glässer’s disease, which is characterized by fibrinous polyserositis, polyarthritis and meningitis in pigs. This study was focused on the characterization of the acute-phase response after immunization and infection of colostrum-deprived pigs with H. parasuis serovar 5, by measuring serum concentrations of three positive acute-phase proteins (APPs) (pig major acute-phase protein pig, MAP; haptoglobin, HPG; C-reactive protein, CRP) and one negative APP (apolipoprotein A-I, ApoA-I). Six experimental groups were established: a non-immunized but infected control group (CTL); two groups immunized with either a recombinant transferrin-binding protein (Tbp) A or TbpB fragment from H. parasuis Nagasaki strain (rTbpA and rTbpB, respectively); two groups immunized with native outer membrane proteins with affinity to porcine transferrin (NPAPT), one of them inoculated intramuscularly (NPAPTim) and the other intratracheally (NPAPTit), and the last group receiving a commercially available bacterin (PG). The greatest concentrations of the three positive APPs and the lowest concentration of the negative APP were detected in CTL group, as well as in those animals belonging to rTbpA or rTbpB groups that died in response to challenge. Significant differences (P < 0.005) were found in these groups when comparing challenge with the following days after it. However, no significant differences were seen for the remaining vaccinated groups (NPAPTim, NPAPTit and PG), which were effectively protected against Glässer’s disease. Therefore, APPs could be used as useful biomarkers for both evaluating disease progression and determining vaccination effectiveness es_ES
dc.language eng es_ES
dc.publisher Elsevier es_ES
dc.subject Sanidad animal es_ES
dc.subject Veterinaria es_ES
dc.subject.other Acute-phase proteins es_ES
dc.subject.other Haemophilus parasuis es_ES
dc.subject.other Glässer’s disease es_ES
dc.title Acute phase protein concentrations in colostrum-deprived pigs immunized with subunit and commercial vaccines against Glässer’s disease es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.description.peerreviewed SI es_ES

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